GOLM METABOLOME DATABASE

metabolic changes during developmental senescence: a case study on Arabidopsis thaliana (single leaves)

see the experiment description.

Choose a data normalisation

The controls below visualise relative metabolite concentrations normalised to fresh weight and internal standards. Please choose from the normalisation radio buttons below to visualise this experiment with respect to different reference points. You might use the mouse wheel to zoom the controls or drag and drop to move the zoomed area. This page is undergoing active development and might change without further notice in the future.


relative to replica group

Please choose from the 12 normalisations for data visualisation!

replica group correlations

The correlation and network plots below visualise the statistical relationship between the replica groups based on the oberserved metabolite profiles. The network plot is derived from the correlation such that only positive correlations are converted into distances, Distance(i,j) = 1 - COR(i,j). The edges are filtered for distances < 0.5. The plot can be zoomed and dragged by using the mouse wheel and left mouse button.

technical replicates (aka chromatogram) correlations

This correlation plot visualise the statistical relationship between the chromatograms based on the observed metabolite profiles. It is kind of 'zoom in' into the replica groups. The assumtion is, that chromatograms within one replica group correlate very well. However, the correlation of chromatograms between replica groups is much worse, depending on the similarity of the replica groups.

metabolite correlations

The correlation and network plots below visualise the statistical relationship between the identified metabolites based on their observed profile accross replica groups. The network plot is derived from the correlation such that only poistive correlations are converted into distances, Distance(i,j) = 1 - COR(i,j). The edges are filtered for distances < 0.2. The plot can be zoomed and dragged by using the mouse wheel and left mouse button.

dendrogram view

The heatmap below can be zoomed and dragged by using the mouse wheel and left mouse button, respectively! Please note, that the order of columns in the control below does neither necessarily reflect the numerical ordering of the replica group column names nor correspond to the column order of the second heatmap.

sortable table based heatmap with boxplot extension

The table below can be sorted by clicking the column headers. Metabolite links point to the metabolite details pages. The table is initially sorted according to decreasing anova F-score values (metabolites with large changes in relative concentration between the replica groups at the top and metabolites with small concentration changes between replica groups at the bottom). Please hoover the mouse over the table to see box plots of the metabolite concentrations according to the replica groups.
metaboliteclassrg1 52d04h central zone of the leaf lamina
details		rg2 52d04h leaf base
details		rg3 52d04h leaf tip
details		rg4 60d04h central zone of the leaf lamina
details		rg5 60d04h leaf base
details		rg6 60d04h leaf tip
details		rg7 70d04h central zone of the leaf lamina
details		rg8 70d04h leaf base
details		rg9 70d04h leaf tip
details		varianceanova F score
Dehydroascorbic acidAcid (Hydroxy)777.4571.10
MannitolPolyol (Hexitol)1,172.6569.39
SerineAcid (Amino)642.0446.85
IsoleucineAcid (Amino)536.4146.14
Glucose, 1,6-anhydro, beta-D-Sugar (Hexose, aldose, anhydride)764.8544.72
Threonic acid-1,4-lactoneAcid (Hydroxy, lactone)534.2443.70
GlycineAcid (Amino)688.2937.15
Fumaric acidAcid (Dicarboxylic)578.6533.24
beta-AlanineAcid (Amino)578.6932.30
Glutaric acid, 3-hydroxy-3-methyl-na957.8330.76
Glutaric acid, 2-oxo-na661.9030.02
D-alpha-Hydroxyglutaric acid disodiumAcid (Dicarboxylic)375.7927.03
LeucineAcid (Amino)349.3121.59
Malic acidAcid (Hydroxy)298.1221.36
ThreonineAcid (Amino)931.9621.05
Erythronic acid-1,4-lactoneAcid (Hydroxy, lactone)204.9020.88
ThreitolPolyol (Tetraol)295.2820.73
ArabitolPolyol (Pentitol)662.8919.59
Shikimic acidAcid (Hydroxy)662.4019.28
beta-indole-3-acetonitrileIndole830.5919.07
GalactinolConjugate (Hexosyl, Inositol)521.4018.30
EthanolamineAlcohol (Amino)148.8016.23
Threonic acidAcid (Hydroxy)441.4914.95
GlucoseSugar (Hexose, aldose)408.3514.47
DiethyleneglycolAlcohol (Ether)108.2714.04
Gluconic acidAcid (Hexonic)280.8013.83
Succinic acidAcid (Dicarboxylic)385.6313.59
myo-InositolPolyol (Inositol)230.2313.22
RaffinoseSugar (Trisaccharide)605.6712.76
Malic acid, 2-methyl-Acid (Hydroxy)432.4112.54
Pentadecane, n-Alkane120.2412.51
Arabinonic acid-1,4-lactonena285.8812.17
Benzoic acidAcid (Aromatic)250.5012.06
NonadecaneAlkane101.3711.99
Alanine, 3-cyano-Acid (Amino)892.1911.51
Trehalose, alpha,alpha'-Sugar (Disaccharide)636.4610.73
Citric acidAcid (Tricarboxylic)275.7510.67
Pantothenic acidAcid (Hydroxy)373.2510.53
FructoseSugar (Hexose)565.6310.36
Butyric acid, 4-amino-Acid (Amino)480.1110.34
Octadecane, n-Alkane109.7310.21
Octacosane, n-Alkane105.509.94
SucroseSugar (Disaccharide)148.749.77
ArabinoseSugar (Pentose, aldose)287.789.50
Phosphoric acidAcid (Phosphate)340.978.67
cis-Aconitic acidAcid (Tricarboxylic)604.808.38
Stearic acidAcid (Fatty acid trimethylsilyl ester)125.618.31
ProlineAcid (Amino)463.138.28
ValineAcid (Amino)744.398.05
Salicylic acid-glucopyranosidena526.197.23
PhenylalanineAcid (Amino)316.017.12
Docosane, n-Alkane122.796.86
PsicoseSugar (Hexose, ketose)227.056.85
Palmitic acidAcid (Fatty acid trimethylsilyl ester)118.336.81
Isoascorbic acidAcid (Hydroxy)343.616.80
Saccharic acidAcid (Hexaric)222.336.32
MannoseSugar (Hexose, aldose)304.086.18
Dotriacontane, n-Alkane117.055.76
Nonanoic acidAcid (Fatty acid trimethylsilyl ester)248.475.41
Sinapic acid, cis-Acid (Phenylpropanoic)352.865.23
Benzoic acid, 2,3-dihydroxy-na1,022.725.14
Sinapic acid, trans-Acid (Phenylpropanoic)297.514.89
FucoseSugar (Hexose, deoxy)163.384.88
AgmatineAmine (Poly)533.964.75
Salicylic acidAcid (Aromatic)602.944.59
Erythronic acidAcid (Hydroxy)267.694.38
DodecaneAlkane145.124.36
Glucose-6-phosphateSugar (Phosphate)232.144.30
4-HydroxypyridineAlcohol (N-heterocycle)117.054.29
Galactaric acidAcid (Hexaric)297.394.19
GlycerophosphoglycerolPolyol (Phosphate)267.824.14
Lactic acidAcid (Hydroxy)413.024.04
Glycolic acidna365.773.92
3-HydroxypyridineAlcohol (N-heterocycle)167.813.86
Ascorbic acidAcid (Hydroxy)475.623.81
Aspartic acidAcid (Amino)311.303.51
Fructose-6-phosphateSugar (Phosphate)268.083.38
Itaconic acidAcid (Dicarboxylic)658.773.27
Galactonic acidAcid (Hexonic)192.602.95
Tetradecanoic acidAcid (Fatty acid trimethylsilyl ester)198.772.82
GlycerolPolyol (Triol)327.882.68
Pyrrole-2-carboxylic acidna421.272.61
Glyceric acidAcid (Hydroxy)491.552.36
Alanine, 2,3,3,3-d4-Acid (Amino)378.962.36
Hexatriacontane, n-Alkane163.542.21
Phosphoric acid monomethyl esterAcid (Phosphate)385.772.17
MaltoseSugar (Disaccharide)528.592.15
Quebrachitol, L-Polyol (Methoxyinositol)223.711.92
SorbitolPolyol (Hexitol)5.691.84
Adenosine, 5-methylthio-na511.681.82
Benzoic acid, 4-hydroxy-Acid (Aromatic)270.231.55
XyloseSugar (Pentose, aldose)182.701.52
SerineAcid (Amino)546.691.47
Glycerol-3-phosphateAlcohol (Phosphate)290.741.29
Gluconic acid lactoneAcid (Hexonic, lactone)168.261.25
GalactoseSugar (Hexose, aldose)192.241.22
UracilPyrimidineNaN288.491.17
Nicotinic acidAcid (N-heterocycle)385.960.99
Glutamic acidAcid (Amino)502.870.98
Siloxanena356.200.93
Pyroglutamic acidLactam451.510.90
Benzene-1,2,4-triolna316.570.88
SalicinSugar (Glucoside)346.590.72
2-HydroxypyridineAlcohol (N-heterocycle)305.550.69
Azelaic acidAcid (Dicarboxylic)435.910.46
105 metabolite(s) in 9 replica group(s).
0.7385 
98.1967

Excluded Metabolites

Internal Standards

Referenced Chromatograms

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service last updated 31/08/2021 © 2008-2014 Golm Metabolome Database - All rights reserved
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